A doctor creates this chart with the individual. Insulin glargine has a long and steady blood-sugar-lowering action. Its self-dosing by patients may be associated with a higher risk of overdose, both accidental and deliberate. Ryzodeg 100IU/ml Penfill is a combination of two medicines, a long-acting and a rapid-acting type of insulin used to treat types 1 and 2 diabetes mellitus in both adults and children. The dose window on the pen shows your insulin dose. Insulin is mostly used to treat type 1 diabetes but can be used in people with type 2 diabetes if insulin levels remain low despite the use of other types of medications. Glucagon is a natural hormone your body makes that works with other hormones and bodily functions to control glucose (sugar) levels in your blood. Diabetes. citrus. b, c, e g. Insulin is always in portal blood, and during fasting insulin inhibits hepatic glucose release by. Deliver insulin more accurately. 12A). The body breaks these nutrients down into sugar molecules, amino acid molecules, and lipid molecules, respectively. Its effects only last a few hours. Tap the syringe to remove air bubbles, making sure. But the four main insulin types are: rapid-acting. It helps prevent serious complications. 0. e. Insulin is a hormone released by the pancreas. It has a long and steady (constant) effect on the blood sugar levels and the action lasts for an entire day. Missing a dose or taking too much at once can cause complications. g. shop Cart; Checkout; Front page; Myaccount; SamplePage; Shop $ 0. 100 U (3. The preferred site for insulin injection is your abdomen. NovoLog FlexPen is used to improve blood sugar control in adults and children with diabetes mellitus. 23% for insulin glulisine and . In patients with type 2 diabetes mellitus, insulin may be used to augment therapy with oral glycemic medications or as insulin replacement therapy. Exercising regularly. Insulin analogs are modified versions of human insulin that are made to act a certain way in the body. The pancreas is an organ behind the stomach that is the main source of insulin in the body. It replaces the insulin that is normally produced in the body. Lantus was Sanofi’s second best-selling pharmaceutical product in 2022 according to the company’s latest annual financial report. Medical nutrition therapy specifically focuses onOver 9 million Americans rely on insulin, and they have been raising red flags over soaring prices for years. This article presents a randomized, double-blind, single-dose, two-treatment, four-period, replicate crossover. More research was required, though, before. After you put in the cartridge. Thank You For Your Interest In Our Products, This Page is for Healthcare Professionals. Low blood potassium may happen with HumaLOG KwikPen (insulin lispro (U-200) pens). Semglee is for use in adults with type 1 or 2 diabetes and in children at least 6 years old with type 1 diabetes (not type 2). Together, they ensure rapid and consistent sugar control that helps control blood sugar levels for an entire day. Insulin-induced hypoglycemia causes up to 100,000 emergency department calls per year. “Not just for insulin but for most diabetes medications. 70, and the new. It works by signaling your pancreas to release insulin when you eat. Step 6 – Remove the Needle. Takeaway. This helps the glucose get into your cells so your body can use it for energy. 6. It replaces the insulin your body doesn't make. 60 SAR. 5 mg) of insulin aspart, glycerol, phenol, metacresol, zinc (as chloride), disodium phosphate dihydrate, sodium chloride, hydrochloric acid, sodium hydroxide for pH adjustment and water for injections. In patients with type 2 diabetes mellitus, insulin may be used to augment therapy with oral glycemic medications or as insulin replacement therapy. thickening or hollowing of the skin where you injected the medicine. 7 mmol/L (≥300 mg/dL) can be additionally added to the scheduled insulin dose. 7. 1. Vívaro Media 8550 Cote de Liesse, Suite 200 St-Laurent, Quebec Canada H4T 1H2. Bariatric Surgery. Playing in a non-sober state or in a state of emotional disturbance is not permissible. Continue Reading. Product leaflet summary. Vivaro is not the insulin of choice for the treatment of diabetic ketoacidosis. Insulin therapies are now able to more closely mimic physiologic insulin. The year 2021 marks the centenary of the discovery of insulin as a therapy, leading to its first successful clinical application and changing the lives of people with diabetes mellitus. 9% saline) or 0. Regular- or short-acting, which takes about 30 minutes to work fully and lasts 3. Sort By. ** Read the package leaflet before use. 2 and 0. Nausea and vomiting. 5 or 2. Regimens often. Step 2 – Attach a New Needle. Step 6 – Remove the Needle. This chapter reviews the pharmacology of available insulins, types of insulin regimens, and principles of. The study of interaction kinetics involves measuring the interaction between ligand and receptor as a function of time throughout a range of analyte concentrations, and then fitting the complete data set to a mathematical. It begins to lower your blood glucose level within 10-20 minutes of. Fiasp is used to improve blood sugar control in adults and children with diabetes mellitus. It replaces the insulin that is normally produced in the body. 3. 3. 216. They ate. Insulin glargine is a long-acting insulin injected once daily and provided a basal insulin level throughout the day. This activity outlines the indications, mechanism of. Insulin is the energy-storage hormone. Orders for pump therapy must be placed in the patient records (at UMHS, use MiChart; entry is located as part of the END subcutaneous insulin therapy order set). The management of type 1 diabetes mellitus entails replacing the actions of the beta cells of the pancreatic islet to detect the need for insulin and to have insulin administered according to the. It is not known if APIDRA is safe or effective in children less than 4 years of age with type 1 diabetes or in children with type 2 diabetes. Please bring enough pump supplies and insulin to last throughout your hospital stay. 4 units to 1. Screening for GDM should occur after 24 weeks of gestation in all women without known diabetes mellitus. 46% for insulin glulisine and -0. A cartridge of insulin is put in the inhaler. From January 2014 to April 2019, the average cash price per insulin unit rose 54%, from $0. When used as a mealtime insulin, the dose of Apidra should be given within 15 minutes before or within 20 minutes after starting a meal. was killed by a nursing assistant in 2018. This. The pancreas can't make enough insulin to keep blood sugar levels within a healthy range. Insulin glargine is a synthetic version of human insulin that is FDA approved to treat adults and children with type 1 diabetes and adults with type 2 diabetes to improve and maintain glycemic control. Treatments have included exercise, horse riding, tobacco, opium, and fasting. 6 unit/kg/day; obese may require 0. Turn the vial and syringe upside down, then draw out the required amount of cloudy insulin. Mechanism Of Action Of Insulin Glargine. The Apidra SoloSTAR® Pen. The exercise can include walking, taking an exercise class. Humulin 70/30. Insulin is a vital hormone that regulates glucose metabolism and influences various aspects of health and disease. 9% saline in a 1-to-1 ratio (250 U of regular insulin in 250 mL of 0. 3 million Americans – or 11. These differences across products create the need for. مطاعم غرف مغلقه بالرياض, e 2 التصديق الالكتروني جدة, تتبيلة فرنسية, سعر صرف الدولار سوريا, طرق لابعاد الناموسDiscovery of Insulin. The Humalog U-200 prefilled pen contains 2 times as much insulin per 1 milliliter as standard (U-100) insulin. All people with type 1 diabetes and some people with type 2. Not everyone with type 2 diabetes needs medication, however. Prescribing Information. Common Humulin R side effects may include: low blood sugar; swelling in your hands or feet; weight gain; or. HSN Code 30043100 : 30043100. Insulin is the most effective glycemic-lowering drug, and for people suffering from type 1 diabetes it is a life-saving drug. Step 4 – Select Your Dose. Thank You For Your Interest In Our Products, This Page is for Healthcare Professionals. Short and rapid-acting insulins start to lower blood sugar levels within 15 to 30 minutes. Over 9 million Americans rely on insulin, and they have been raising red flags over soaring prices for years. Insulin is a medication used in the treatment and management of diabetes mellitus type-1 and sometimes diabetes mellitus type-2, both of which are significant risk factors for coronary artery disease, stroke, peripheral vascular disease, and a host of other vascular conditions. 2. يتوفر دواء VIVARO 100 IU/ml pre-filled pen. Very low blood sugar can lead to seizures, passing out, long lasting brain damage, and sometimes death. Insulin inhalers are used to take a form of insulin that is breathed-in through your lungs (inhaled). pancreas. “Prices are too high,” Redmond says. Insulin is a vital treatment for people with diabetes, but insulin overdose can be dangerous. Currently there are two systems of continuous glucose monitors. Mouth b. [ 14 ]. Aims Subcutaneous administration of insulin in patients suffering from diabetes is associated with the distress of daily injections. The Guardian™ 4 Sensor is intended for insertion into persons ages 7 years and older. Types of Insulin. Usually taken 10 to 30 minutes before breakfast and dinner. The Important Safety Information for Insulin Glargine U-100 is the same as for Lantus. Insulin glargine. . 1 unit/kg followed by an infusion of 0. However, if it leads to hypoglycemia, it may cause: sugar cravings. 216. Insulin is an anabolic hormone that elicits metabolic effects throughout the body. Basal insulin is a slow steady stream of insulin. A concise way to evaluate pharmacotherapy options for type 2 diabetes mellitus is to use the five patient-oriented STEPS criteria: safety, tolerability, efficacy, price, and. Advantages of insulin pumps. Low blood potassium may happen with insulin NPH (vials). Humulin 70/30 is less popular than other insulins. يشار إلى أن الأنسولين غلارجين لتحسين السيطرة على نسبة السكر في الدم لدى البالغين والأطفال المصابين بداء السكري من النوع 1 وفي البالغين المصابين بداء السكري من النوع 2. Call your doctor for medical advice about side effects. Here, we sought to compare originator and non-originator copies of insulin glargine for innate immune activity and mechanisms leading to. Basaglar is injected under the skin. Although there are counterregulatory endocrinologic responses to hypoglycemia,. It can cause depression, shaking, sweating, and a racing heartbeat. At least 1 insurer reimburses flights to the border to make such purchases easy. It helps your body turn food into energy and controls your blood sugar levels. This helps the glucose get into your cells so your body can use it for energy. This helps the glucose get into your cells so your body can use it for energy. Insulin glargine is a synthetic version of human insulin that is FDA approved to treat adults and children with type 1 diabetes and adults with type 2 diabetes to improve and maintain glycemic control. Premixed. NovoLog dosing schedule. It's generally recommended to store unopened insulin in a cool, dry place at temperatures between 36 and 46 degrees. Insulin glargine is used to treat diabetes mellitus in adults, adolescents and children agedyears and above Vivaro is a clear, colourless solution for injection containing insulin glargine. Mounjaro (tirzepatide) is a convenient, once-a-week injectable medication for Type 2 diabetes. Increased physical activity 2. The cells then use this sugar for energy. The usual starting dosage of Livalo for high cholesterol is 2 mg once each day. Thank You For Your Interest In Our Products, This Page is for Healthcare Professionals. Insulin glargine. There are specialised areas within the pancreas called islets of Langerhans (the term insulin comes from the Latin insula that means island). The diacyl side chain of insulin degludec, in the. 1 Humulin 70/30 100U/ml 7. skin problems such as eczema, rash, itching, redness and swelling of your skin (dermatitis), reactions at the injection site such as itching, rash, skin thickening or pits at the injection site (lipodystrophy), or weight gain. Solution; Administration Route. 60 SAR. The insulin receptor is a glycosylated, disulfide-linked α 2 β 2 tetramer that belongs to a subfamily of receptor tyrosine kinases, including insulin-like growth factor 1 (IGF-1) receptor and insulin receptor–related receptor (IRR) (8, 9) (Figure 1A). It is the story of famous, almost famous and little known people, of serendipities, discoveries and re-discoveries. The islets of Langerhans are made up of different type of cells that make hormones, the commonest ones are the beta. Measurement of insulin and GLP-1 secretion and insulin content MIN6-CB cells were cultured in 24-well plates (5 × 10 5 cells/well) for 4 days. Check out this step-by-step guide to become a Pen pro. hospitals because diabetes is becoming common in America. Greater than 130 Increase lunch rapid/regular insulin dose by 2-4 units. allow cells to take in glucose. This causes. Insulin is a peptide hormone containing two chains cross-linked by disulfide bridges. Therapeutic Indications: Vivaro is a clear, colourless solution for injection containing insulin glargine. Insulin binds to the insulin receptors on muscle, liver, and fat cells and lowers blood glucose by facilitating the cellular uptake of glucose and simultaneously inhibiting the output of glucose from the liver. This method may be recommended for people with T1D and T2D. It regulates the metabolism of carbohydrates, fats. The over-the-counter insulin from Walmart that costs about $25 per vial is limited to two types of insulin: Regular (insulin R) NPH (insulin N) You can also get a premixed combination of NPH and Regular called 70-30. REPLACEMENT. l ɪ n /, from Latin insula, 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the insulin (INS) gene. Glucagon prevents your blood sugar from dropping too low. per page. • The Insulin glargine SoloStar prefilled pen dials in 1-unit increments. Insulin is typically delivered via a syringe or an insulin pen. Mounjaro was the first medication approved in a new class of medications. Novolin N is made by Novo Nordisk, while Humulin N is made by Eli Lilly and Company. It begins to lower your blood glucose level within 10-20 minutes. 216. 7 mmol/L (200–300 mg/dL) or 0. The body also stores and reassembles. Insulin is a life-saving medicine that more than seven million Americans take to manage their diabetes. Insulin is available as synthetic human insulin. Advances extended across a broad front, from the stabilization of animal insulin formulations to the frontiers of synthetic peptide chemistry, and in turn, from the advent of recombinant DNA manufacturing to structure-based protein analog design. The Evolution of Insulin Development. Deliver bolus insulin easier. Insulin Glargine; Product Type. Please acknowledge that you are a Healthcare Professional to continue Continueالنهدي ساله تجميع ا 75 سوال 1-Sultan is 34 years old man came to your pharmacy Suffering from pyrosis and take Omeprazole for 14 days and it was helpful, what do you recommend? Refer 2-Anti-nematode agent? Vermox R ( mebendazole ) *class of Anthelmintics 3-Alternative of Panadol sinus is? Adol sinus 4-Eye drop not used for more. Insulin 40IU/ml Injection is an intermediate-acting insulin, that starts working in 1-2 hours after injection. Then, from January 2020 to July 2023, it dropped by 10. U40 stands for: 40 Units of insulin per 1mL (milliliter) U100 stands for: 100 Units of insulin per 1mL (milliliter) U500 stands for: 500 Units of insulin per 1mL (milliliter) So, if you have a U100 insulin product, and you need to inject 50 units, that would come out to 0. 8). Insulin is a chemical messenger that allows cells to absorb glucose, a sugar, from the blood. CGM units sound an alarm if blood glucose levels are changing rapidly, helping people avoid hypoglycaemia or hyperglycaemia. It replaces the insulin your body doesn't make. Optional FlexCargo creates more space. NovoLog (insulin aspart) is a fast-acting insulin for adults and children with diabetes. It also slows down how fast your stomach empties and lowers the amount of glucose (sugar) made by your liver. Dose: 0. The types of insulin include: Rapid-acting, which starts to work within a few minutes and lasts a couple of hours. diarrhea, constipation. regular- or short-acting. Diabetes education may consist of patient management to begin insulin pump therapy (also called continuous subcutaneous insulin infusion or CSII) as it relates to insulin, such as carb ratios, basal rates, sick day management, or insulin sensitivity for correction factor. Prescribing Information. Nowadays is a leading supplier of healthcare products in the MENA region. Collip. Macleod at the University of Toronto in 1921 (Figure 1), and it was subsequently purified by James B. Physiologically, 100% of endogenous insulin flows from the pancreas to the liver via the pancreatic and portal veins. has a long and steady blood-sugar-lowering action. However, sugar and insulin are also important. vivaro have substitution of glycine for asparagine at A21 and two arginines added to the carboxy terminal of B-chain. The medication is available over-the-counter without needing a prescription. Insulin glargine has a long and steady blood-sugar-lowering action. Humalog Tempo Pen. 7 to 19. Controlling high blood sugar helps prevent kidney damage, blindness, nerve. Do not take Lantus during episodes of low blood sugar or if you are allergic to insulin or any of the inactive ingredients in Lantus. The role of insulin is to lower blood-glucose concentrations in order to prevent hyperglycaemia and its associated microvascular, macrovascular and metabolic. Subcutaneous;. Basaglar Kwikpen. Used for Diabetes Type 2, Diabetes Type 1. 46% for insulin glulisine and -0. 4 - other international versions of ICD-10 Z79. Learn about cost, dosage, and more for NovoLog (insulin aspart), a prescription drug that helps manage blood sugar levels in adults and children with diabetes. Apidra is a short-acting insulin that is used in combination with intermediate- or long-acting insulins or insulin analogues (modified forms of insulin). The types of insulin include: Rapid-acting, which starts to work within a few minutes and lasts a couple of hours. We as an organization stand out in the midst of the uncertainty of global situation with sustainable momentum and passion to success. The patient’s blood glucose (sugar) levels should be regularly tested to find the lowest effective dose. FIND MORE FEATURES. It is not known if Humalog or Insulin Lispro Injection. After a meal, it helps the cells use carbs, fats, and protein as needed, and store what's left (mainly as fat) for the future. Apidra is a rapid-acting insulin analog indicated to improve glycemic control in adults and pediatric patients with diabetes mellitus. Fast-acting insulin: Is absorbed quickly from your fat tissue (subcutaneous) into the bloodstream. 5 and 1 unit/kg/day; nonobese may require 0. It is a long-acting insulin and has a relatively long duration of action as compared with other insulin. R. Insulin is a. Keep in mind that water and other zero-calorie drinks are best. Apidra may be infused subcutaneously by external insulin infusion pumps. We would like to show you a description here but the site won’t allow us. low blood sugar - headache, hunger, sweating, irritability, dizziness, fast heart rate, and feeling anxious or shaky; or. 2008;4(3):258-268. The role of Insulin is to __________. Eli Lilly cuts the price of insulin, capping drug at $35 per month out-of-pocket. Cells were starved in low-glucose KRBB for 30 min. Keep fruits, vegetables and whole grains in your refrigerator and pantry. In 1997, after 56 years of success, FDA’s insulin certification program came to an end with the passage of the Food and Drug Administration Modernization Act (FDAMA). We as an organization stand out in the midst of the uncertainty of global situation with sustainable momentum and passion to success. This post hoc analysis aimed to provide the first evidence for switching from IGlar to LY IGlar in Chinese patients with. In case of insufficient glucose control or a tendency to hyper- or hypoglycaemic episodes, the patient's adherence to the prescribed treatment regimen, injection sites and proper injection Apidra 100IU/ml Solution for Injection is a modern, rapid-acting form of insulin that helps to control high blood glucose (sugar) levels. 6-1. Treatment of type 2 diabetes mostly involves lifestyle. Samples of 0. 5 ml were placed in Eppendorf tubes upon nitrogen atmosphere and incubated at 4°C for 24 h. 2. The award-winning van, 206 miles range, 1,226kg payload, 1 tonne towing capability. Humulin 70/30 is a combination of two types of insulin used to control blood sugar right after meals and throughout the day, but it might take time to find the right dose that works for your body. It. Experts believe it is influenced by. It begins to lower your blood glucose level within 10-20 minutes. , June 29, 2021 — Walmart announced the launch of the first-ever private brand analog insulin, which will revolutionize the access and affordability to diabetes care by offering customers a significant price savings without compromising quality. Treatments for type 1 and type 2 diabetes. The Toujeo brand of insulin glargine contains 3 times as much insulin per milliliter (mL) as the Basaglar brand. Insulin glargine is a long-acting insulin injected once daily and provided a basal insulin level throughout the day. It regulates glucose concentrations in the blood. Your provider can prescribe human-made insulin that you take through an injection (shot), injectable pen or pump. The current list price of a Humalog vial is $274. When used as a mealtime insulin, the dose of Apidra should be given within 15 minutes before or within 20 minutes after starting a meal. It gives you a base amount of insulin to supplement the insulin your body produces naturally. The Humalog U-200 prefilled pen contains 2 times as much insulin per 1 milliliter as standard (U-100) insulin. Insulin Degludec injection (Tresiba®): within 56 days of opening insulin pens or vials; How to Store Insulin Properly (Insulin Storage Guide) Temperature is the most critical factor when it comes to insulin storage. - 3 ml pen/cartridge contains 300 units of insulin - 5 ml vial contains 500 units of insulin - 10 ml vial contains. Call your doctor at. Pen f. Sólo profesionales - Envío gratuito desde 120 € 696 46 91 91 981 29 48 00. IV insulin therapy involves inserting a thin tube, which doctors refer to as a catheter, into the arm. In the future, many will even work in concert with continuous glucose monitoring systems (CGM). رمزيات ابو شنب, the vampire diaries مترجم, laroche posay غسول, ابتعاث كلية الملك فهد البحرية, موقف سابتكو جدةto your insulin dosing or diabetes. Diabetes mellitus is a disease where your body does not produce enough insulin to control the level of blood sugar. Insulin therapies are now able to more closely mimic physiologic insulin secretion and thus achieve better glycemic control in patients with diabetes. Insulin may also be given to pregnant women who develop a type of diabetes during pregnancy called gestational diabetes. Insulin plays a central role in the regulation of human metabolism. Since the introduction of insulin analogs in 1996, insulin therapy options for patients with type 1 and type 2 diabetes have expanded. Glucose is a type of sugar. 23% for insulin glulisine and -0. The CIP is a new technology with a function that. Humalog Tempo Pen. 2 Humulin 7. The MiniMed 780™ insulin pump is indicated for use by patients age 7-80 years with Type 1 diabetes, whose total daily dose of insulin is 8 units per day or more. Humalog Mix 75/25 KwikPen is a combination medicine used to improve blood sugar control in adults with diabetes mellitus . It’s important to take the correct dose at the appropriate time. Lyumjev and Humalog are both diabetes drugs that contain the active ingredient insulin lispro. 23% for insulin glulisine and -0. Basal insulin (long-acting or ultra-long-acting) helps to manage blood glucose between meals. The pump order set documents the basal rates. The bottom line. Most current research has focused on the in vivo imaging of whole cells while there are few detailed studies on. Compact exterior design. Insulin glulisine was shown to be comparable to regular human insulin with regard to glycated haemoglobin (expressed as HbA 1c equivalent) changes from baseline to the 6-month endpoint (-0. If not treated, this can lead to a heartbeat that is not normal, very bad breathing problems, and sometimes death. We would like to show you a description here but the site won’t allow us. Établie en 2000 et avec une couverture mondiale Vívaro Media offers a full range of video transmission services via fiber optics, satellite, wireless or the internet. This helps to control blood sugar levels for an entire day. Step 1 – Prepare for an Injection. Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Americans with private insurance or Medicare paid an average of $63 per insulin fill. 85. Low blood sugar. Their effects last for 2 to 4 hours, which can help. Nicole Smith-Holt’s son, Alec, died in 2017 from diabetic ketoacidosis, a condition that occurs when the body doesn’t have enough insulin. Rossi et al. May administer 0. Give NPH twice daily (e. allow cells to take in glucose. Insulin helps your muscles and fat cells store extra glucose so it doesn’t overwhelm your bloodstream. NovoMix medicines contain the active substance insulin aspart (100 units/ml) combined with protamine to make it longer acting. 60 SAR. Category Of Lantus Solostar Pens. Long-acting insulin takes effect several hours after injection. Select your FREE GIFT! View as Grid List. To make the student more alert 3. 0-litre engine is the more refined and gutsier option, it’s interesting that it and the 1. Add to Cart. The Apidra SoloSTAR® Pen. Insulin glargine is a long-acting insulin that starts to work several hours after injection and keeps working evenly for 24 hours. Since 1922, insulin administration constitutes the. Sliding scale insulin therapy involves creating and following an individual chart. When the amount of glucose in the blood increases, e. , Cushing’s disease and hypothyroidism). The order set for insulin infusion pump settings and use must be completed in the EHR by the admitting service or Endocrinology. Lantus was Sanofi’s second best-selling pharmaceutical product in 2022 according to the company’s latest annual financial report. 6m3 load volume. 3 billion. We also generated functional insulin-producing cells from the mBMDS cells under an in vitro differentiation procedure and confirmed the presence of insulin. Lispro insulin is a short-acting insulin that you take before meals. The long-acting insulin. Insulin Glargine 100 IU/Ml Pens . it is essentially ‘sodium-free’. Insulin allows sugar into the cells for energy, reducing the amount of sugar in the bloodstream. Tests confirmed he died of insulin doses. In such cases add-on of 0. BASAGLAR ® is a registered trademark owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates. Insulin glulisine was shown to be comparable to regular human insulin with regard to glycated haemoglobin (expressed as HbA 1c equivalent) changes from baseline to the 6-month endpoint (-0. Common side effects include: initial weight gain as the cells start to take in glucose. Insulin isophane is used with a proper diet and exercise program to control high blood sugar in people with diabetes.